Pulmonary Embolism & Deep Vein Thrombosis Technology

Clots aren’t all the same.

A blood clot in a deep leg vein (DVT) can block blood flow and cause lasting pain and swelling. If a piece breaks off, it can travel to the lungs (PE), which can be deadly.

Some clots are soft and fresh. Others are partly hardened, or old and stuck to the vein wall. Doctors often can’t tell which kind they face until they’re inside the vein. In one study of leg-clot patients, about 35% had old, hardened clot and about 30% more had a mix.¹

Today’s devices work well on soft clot and some partly hardened clot. Clot left behind can mean repeat procedures.

¹ Mansiroglu A, et al. J Vasc Surg Venous Lymphat Disord. 2020;9:874–880.

HOW CLOTHOUND WORKS: PROTECT, LOOSEN, REMOVE.

How It Works

1 Protect. The far sphere opens beyond the clot, downstream of the aspiration catheter tip, as a safety net so loose pieces can’t travel to the lungs.

2 Loosen. The near sphere opens between the catheter tip and the far sphere, up to 5 cm behind the far sphere. The near sphere gently curettages the clot from the vein wall.

3 Remove. The near sphere is collapsed. Suction pulls the loosened clot into the aspiration catheter while the far sphere stays open downstream as a safety net. The aspiration catheter stays in place, so it doesn’t have to be pulled out to clear clogs.

One device, designed for the whole clot.

Built for every kind of clot.

Designed to remove soft, partly hardened and hard clot, so doctors don’t have to guess first.

A built-in safety net

Built for every kind of clot.

The far sphere is designed to catch pieces that break loose before they can reach the lungs.

One catheter, kept in place

Built for every kind of clot.

One catheter, kept in place

The aspiration catheter stays in place while the spheres work, so doctors don’t keep pulling the device out to clear clogs.

What early testing shows

These are early, small studies. Results in people have not been established.

Company bench testing: ClotHound cleared all three challenge-case clot models: Model 1 (15 mg fibrin), Model 2 (20 mg fibrin) and Model 3 (25 mg fibrin).
In a chronic animal model, ClotHound removed a 20 cm segment of chronic, wall-adherent clot. At postmortem, there were zero visible emboli in the lungs. (Unpublished data from a strategic partner’s lab; one animal.)
Safety studies in 4 pigs found no significant vessel damage.
The spheres push with at most 22 N, far less than could tear a vein.
The 24F aspiration catheter bent through tight turns without kinking or collapsing. Three peer-reviewed papers on ClotHound (2022, 2024, 2024), all preclinical.

A better way to remove dangerous blood clots

A better way to remove dangerous blood clots

Clots aren’t all the same.

HOW CLOTHOUND WORKS: PROTECT, LOOSEN, REMOVE.

How It Works

Device Close-Up

Watch the 3-minute animation. It shows how the spheres and suction work together.

One device, designed for the whole clot.

Built for every kind of clot.

Built for every kind of clot.

Built for every kind of clot.

A built-in safety net

Built for every kind of clot.

Built for every kind of clot.

One catheter, kept in place

Built for every kind of clot.

One catheter, kept in place

One procedure for soft, partly hardened and hard clot.

According to Retriever’s physician advisors, today’s aspiration-only devices work on soft clot and only partly on partly hardened clot. ClotHound is designed for all three kinds, in one procedure. How it performs in people has not been established.

What early testing shows

These are early, small studies. Results in people have not been established.

Legs first, then lungs.

our team

Ben Bobo, Co-Founder & CEO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Hieu Le, Vice President, R&D

Brandon Repko, MD, Co-Founder & CSO

Michael Horowitz, MD, Co-Founder/ Director

Michael Horowitz, MD, Co-Founder/ Director

Michael Horowitz, MD, Co-Founder/ Director

Rich Ferrari, Executive Chairman

Kenneth L. Weiner, MD, Director

talk to Us

A better way to remove dangerous blood clots

A better way to remove dangerous blood clots

Clots aren’t all the same.

HOW CLOTHOUND WORKS: PROTECT, LOOSEN, REMOVE.

How It Works

Device Close-Up

Watch the 3-minute animation. It shows how the spheres and suction work together.

One device, designed for the whole clot.

Built for every kind of clot.

Built for every kind of clot.

Built for every kind of clot.

A built-in safety net

Built for every kind of clot.

Built for every kind of clot.

One catheter, kept in place

Built for every kind of clot.

One catheter, kept in place

One procedure for soft, partly hardened and hard clot.

According to Retriever’s physician advisors, today’s aspiration-only devices work on soft clot and only partly on partly hardened clot. ClotHound is designed for all three kinds, in one procedure. How it performs in people has not been established.

What early testing shows

These are early, small studies. Results in people have not been established.

Legs first, then lungs.

our team

Ben Bobo, Co-Founder & CEO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Brandon Repko, MD, Co-Founder & CSO

Hieu Le, Vice President, R&D

Brandon Repko, MD, Co-Founder & CSO

Michael Horowitz, MD, Co-Founder/ Director

Michael Horowitz, MD, Co-Founder/ Director

Michael Horowitz, MD, Co-Founder/ Director

Rich Ferrari, Executive Chairman

Kenneth L. Weiner, MD, Director

talk to Us

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