Deep Vein Thrombosis (DVT):
Blood clot located in a deep vein in a leg.
Pulmonary Embolism (PE):
Blood clot that has traveled from a deep vein to a lung.
Blood clot located in a deep vein in a leg.
Blood clot that has traveled from a deep vein to a lung.
in the U.S. annually¹
in the U.S. annually¹
Cardiovascular cause of death behind heart attack and stroke²
In 30% of cases, there are impacted, chronic clots causing blockages in the lungs, and these patients can be discharged with these obstructions still present.
In 70% of cases, there are chronic, wall adherent clots, causing blockages in the leg and these patients can be discharged with obstructions still present.
An acute clot, also known as a soft clot, refers to a blood clot that forms suddenly and is typically composed of fresh fibrin and platelets. These clots are often associated with recent injury, surgery, or trauma, and they can rapidly obstruct blood flow. Acute clots require immediate medical attention to prevent complications such as pulmonary embolism or stroke.
A sub-acute clot, also referred to as a medium clot, represents an intermediate stage in the clotting process between acute and chronic clots. These clots may have started to organize (where the fibrin protein starts to biochemically crosslink with other fibrin proteins) and incorporate elements like red blood cells, but they haven’t fully matured into chronic clots. Sub-acute clots may present with varying degrees of obstruction and symptoms depending on their size and location.
Chronic clots, also known as hard clots, are well-established and organized (heavily crosslinked) blood clots that have been present for an extended time period. These clots have undergone significant restructuring, with layers of fibrin, collagen, and other components and are devoid of RBCs. Chronic clots can persist for weeks, months, or even years, posing a risk of complications such as post-thrombotic syndrome, chronic thromboembolic pulmonary hypertension or recurrent thrombosis if left untreated.